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Principal Scientist, Pharmacology

Janux Therapeutics

Janux Therapeutics

San Diego, CA, USA
Posted on Friday, May 17, 2024

As a member of the pharmacology group, we seek a scientifically curious and motivated individual with an ability to work in a fast-paced environment. The Principal Scientist will develop and execute the bioanalytical method development to support nonclinical and clinical sample analysis, as well as the transfer of assays to CRO’s. In addition, the incumbent will support in vitro and in vivo pharmacology by using ELISA, Octet, flow cytometry or cell-based assays, as well as leading and conducting animal studies with CRO’s.

This position is hands-on and requires the effective study execution, communication, and documentation of results that enable the advancement of novel research molecules toward development candidates. Strong candidates will be creative, collaborative, and passionate about drug discovery and development. Expertise in tumor biology, immunology as well as pharmacology are required. As a strategic team member, you will directly support decision-making for pipeline programs as they progress from early research through an IND and into the clinic.

ESSENTIAL FUNCTIONS AND RESPONSIBILITIES

  • Identification, development and execution of in vitro assays to support both in vivo and in vitro pharmacology studies.
  • Independent design and execution of bioanalytical assays from assay development, qualification (as required), sample analysis, data analysis, report and SOP drafting (as required).
  • Independent management of bioanalytical assay outsourcing activities from assay transfer to sample analysis and report finalization.
  • Analyzation and presentation of experimental data using Prism, Excel, MS Office or similar software, along with delivery of findings to cross-functional groups.
  • Training and supporting junior team members to manage and execute complex experimental testing.
  • Producing detailed documentation of experiments within a lab notebook and electronically.
  • Effective scheduling and prioritization of workload within a fast-paced, multi-tasking environment.
  • Other duties as assigned.

EDUCATION, EXPERIENCE, KNOWLEDGE, SKILLS AND ABILITIES

  • PhD in Immunology, Cell Biology, Biotechnology, or a related discipline + at least 4 years of drug discovery experience, MS + 6 to 8 years of drug discovery experience, or BS + 10 to 12 years of drug discovery experience in an industry setting is required.
  • Extensive experience in ligand binding assay development, assay outsourcing, and qualification/validation is required.
  • Experience working with external CROs on bioanalytical assays and non-human primate studies (due diligence, proposals, oversight, project management, data analyses, and reporting) is highly desirable.
  • Experience of processing and analyzing animal model samples and human clinical samples would be a
  • Strong understanding and prior experience working in immune
  • Hands-on expertise with standard lab techniques such as ELISA, MSD, Flow cytometry, and cell culture.
  • Competence in data analysis tools (Excel, GraphPad).
  • Strong analytical and critical thinking skills with the ability to work in a fast-paced
  • Strong analytical skills and ability to work in a highly collaborative
  • Excellent written and oral communication
  • Ability to travel up to 20% of the time.

Compensation:

In addition to a competitive base salary ranging from $145,000 to $165,000, we offer stock options, a stock purchase plan (ESPP) and a target bonus. Janux also provides a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance.

Please note that the base salary range is a guideline, and individual total compensation will vary based on factors such as qualifications, skill level, competencies, internal equity and work location.

Job Type: Full-time

Benefits:

  • 401K
  • Medical insurance
  • Dental insurance
  • Vision insurance
  • Supplemental disability insurance plans
  • Flexible schedule
  • Life insurance
  • Flexible vacation
  • Sick time
  • Incentive stock option plan

Schedule:

  • Monday to Friday

Work authorization:

  • United States (Required)

Additional Compensation:

  • Annual targeted bonus %

Work Location:

  • On site (San Diego, CA)

EQUAL OPPORTUNITY EMPLOYER:

Janux Therapeutics, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from retaliation for protected activity.

Notice to Recruiters and Third-Party Agencies

The Talent Acquisition team manages the recruitment and employment process for Janux. To protect the interests of all parties involved, Janux will only accept resumes from a recruiter once a fully-executed search agreement is in place. Agencies are hereby specifically directed not to contact Janux employees directly in an attempt to present candidates. Janux will consider any candidate for whom an Agency and/or Recruiter has submitted an unsolicited resume to have been referred, free of any charges or fees.