Group Head, Distinguished Scientist, Non-viral Gene Therapy Formulations, Genomic Medicine Unit
Group Head, Distinguished Scientist, Non-viral Gene Therapy Formulation, Genomic Medicine Unit
We are seeking a Group Head, Distinguished Scientist, to join the newly created non-viral gene therapy research group in the Genomic Medicine Unit. The candidate will play a leadership role in executing and maintaining the strategy to develop targeted and non-targeted, non-viral gene therapy treatments for rare and common diseases.
Specifically, the remit of the candidate will be to:
Lead a dynamic, multi-site LNP formulation, chemistry and protein sciences team comprised of Ph.D. and non-Ph.D. scientists that are impactful contributors on project teams at various stages from early research, lead nomination and clinical candidate.
Responsible for applying scientific expertise and judgement to initiate, design, direct and execute engineering for the formulation and chemistry of targeted/non-targeted nanoparticles to cell and/or tissues to deliver DNA and mRNA cargo, working cross-functionally with biology project teams.
Continue to refine and execute chemistry and formulation strategy within the non-viral gene therapy organization that enables Sanofi to remain on the cutting edge of non-viral gene therapy.
Work closely with biologists to enable design of critical go/no-go experiments to enable progression of drug candidates to the clinic
Refine, and develop/implement strategy (where needed) for high throughput screening of targeting conjugates to lipid nanoparticles
Contribute to lipid design while working cross-functionally with other chemists locally and globally
Liaise cross-functionally with CMC process development teams to ensure smooth transition of programs from research to development when programs are at the appropriate maturity
Act as an impactful contributor and leader for transversal and cross-functional initiatives.
Work across R&D organization to test and advance innovative processes, hypotheses and methodologies; encourages curiosity and challenges the status quo in order to foster innovation.
Enable productivity, execution with a sense of urgency, teamwork, accountability, scientific rigor and excellence.
Foster a culture of employee growth and development
Leading-edge knowledge of principles, concepts, and practices in non-viral gene delivery (specifically to LNP chemistry and nucleic acid formulation); experience of translating treatments from early research to the clinic is strongly preferred.
PhD plus minimum 10 years of relevant (direct LNP formulation and chemistry) research experience in an academic or biopharmaceutical setting demonstrating continuous growth in depth and breadth of knowledge.
Minimum of 5 years of experience in the biopharmaceutical setting with significant team leadership experience is required.
Applies technical, functional and industry knowledge to design and execute projects that shape the strategic direction of the group.
Hands-on manager and experienced leader that exercises foresight and judgement in planning, organizing and guiding complex projects. Track record of successfully applying high- level scientific judgement in a variety of complex and unprecedented situations.
Flexibility to rapidly changing priorities and deadlines and ability to lead others through change in a dynamic, fast paced industry and work environment.
Recognized as an outstanding scientist and subject matter expert / innovator in the field. Outstanding track record of scientific publications, presentations, patents, projects as a leading contributor or senior author. Excellent track record of project impact as a key contributor.
Excellent interpersonal and communication skills: impactful oral and written communication.
Experience in preparing high quality documents including technical reports, presentations, SOPs, experimental protocols and regulatory filings.
Candidates must be authorized to work in the USA.
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.