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2024 Fall Co-op - Data and Computational Science, mRNA Center of Excellence, Sanofi - Vaccines

Synthorx

Synthorx

Waltham, MA, USA
Posted on Wednesday, January 17, 2024

Job Overview:

The Co-op position is based in the Data and Computational Science (DCS) department within the Sanofi mRNA Center of Excellence (mRNA CoE) supporting the activities in the CMC data science group. This position will focus on In Vitro Transcription (IVT) modelling, Model-based Design of Experiments (MBDoE), advanced process control (APC), machine learning and data visualization, supporting the main functions in the CMC data science team. The candidate will have opportunities to learn about mRNA technology, unit operations and to demonstrate the benefits of process modeling and advanced control in a non-GMP lab environment.

Job Description:

The successful candidate will work with his/her supervisor to develop dynamic models for In Vitro Transcription (IVT) reactions. The activities include to investigate how process parameter influence product quality attributes and uncertainty quantification, design model-based DoE for model structure selection and parameter optimization, and scalability and robustness analysis of the developed models.

Basic Qualifications:

  • Currently enrolled in a biology, chemical or biochemical engineering, or equivalent program and working toward BS, MS, or PhD degree program

Preferred Qualifications:

  • Basic understanding of mRNA technology

  • Knowledge in enzymatic reactions such as in vitro- transcription, capping and tailing

  • Experience in First principle and hybrid dynamic modeling, and model-based DoE

  • Familiar with mathematical software and packages (Python, Julia, MATLAB, PYOMO, sklearn, gPROMS)

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.