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Scientist, Downstream Process Development

Janux Therapeutics

Janux Therapeutics

Operations
San Diego, CA, USA
Posted on Friday, May 17, 2024

Scientist, Downstream Process Development

As a member of the Process Development, CMC group, the Scientist will contribute to the development and implementation of downstream purification processes to enable the advancement of Janux therapeutic candidates from Research through Clinical development. The successful job candidate will contribute to the development and technical transfer of purification processes to Contract Development and Manufacturing Organizations (CDMOs) for clinical manufacturing.

Essential Functions and Responsibilities:

  • Design and perform experiments to identify and establish operating and performance parameters for purification steps and overall processes.
  • Execute lab-scale process development and material generation activities to support pre-clinical studies and technical transfer to CDMOs.
  • Perform experiments and interpret results to evaluate process parameters for individual unit operations.
  • Prepare SOPs and technical reports and maintain appropriate records of experiments.
  • Responsible for operation and preventive maintenance of laboratory equipment.
  • Work under general supervision to ensure timely execution of projects.
  • Analyze and communicate experimental results to colleagues and supervisor and provide solutions to problems.
  • Collaborate across functional areas, maintaining a good rapport.
  • Assist with protein inventory management.
  • Other duties as deemed necessary.

Required Skills and Qualifications

  • A Bachelor’s Degree and 6 to 8 years of directly relevant industry experience, a Master’s Degree with 4 to 6 years of directly relevant industry experience, or a PhD with 1 to 2 years of directly relevant industry experience is required. A BSc, MSc or PhD in Cell and Molecular Biology, Biochemistry, or a related discipline is preferred.
  • Demonstrated technical proficiency, scientific creativity, collaboration with others, and independent thought in suggesting experimental design is required.
  • The ideal candidate will have experience in the following:
    • AKTA Chromatography and filtration unit operations
    • Large molecule/biologic drug development
    • Authoring of SOP’s and technical reports
  • Working knowledge of different modes of chromatography, types of resins, and column packing.
  • Strong analytical skills with hands-on experience with SDS-PAGE, HPLC, Octet, and TFF/UFDF is strongly preferred.
  • Familiarity with cGMP bioprocessing and experience working with CDMO’s is preferred.
  • Ability to multi-task, prioritize projects, and troubleshoot process and equipment problems.
  • Ability to work in a highly collaborative environment with rapidly evolving priorities.
  • Excellent written and oral communication skills.

Compensation:

In addition to a competitive base salary ranging from $100,000 to $132,000, we offer stock options, a stock purchase plan (ESPP) and a target bonus. Janux also provides a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance.

Please note that the base salary range is a guideline, and individual total compensation will vary based on factors such as qualifications, skill level, competencies, internal equity and work location.

Job Type: Full-time

Benefits:

  • 401K
  • Medical insurance
  • Dental insurance
  • Vision insurance
  • Supplemental disability insurance plans
  • Flexible schedule
  • Life insurance
  • Flexible vacation
  • Sick time
  • Incentive stock option plan

Schedule:

Monday to Friday

Work authorization:

United States (Required)

Additional Compensation:

Annual targeted bonus %

Work Location:

Onsite; San Diego, CA

EQUAL OPPORTUNITY EMPLOYER:

Janux Therapeutics, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from retaliation for protected activity.

Notice to Recruiters and Third-Party Agencies

The Talent Acquisition team manages the recruitment and employment process for Janux. To protect the interests of all parties involved, Janux will only accept resumes from a recruiter once a fully-executed search agreement is in place. Agencies are hereby specifically directed not to contact Janux employees directly in an attempt to present candidates. Janux will consider any candidate for whom an Agency and/or Recruiter has submitted an unsolicited resume to have been referred, free of any charges or fees.