Project Team Leader (PTL)
Janux Therapeutics
San Diego, CA, USA
Posted on Nov 1, 2025
Janux Therapeutics is seeking a distinguished Project Team Leader (PTL) to provide visionary leadership and strategic direction for the development and execution of asset development plans across our oncology portfolio. The PTL will serve as the single point of accountability for the seamless delivery of project milestones and outcomes for one or more assets, guiding them from early clinical development through submission and comprehensive life-cycle management.
This executive role demands a leader with exceptional expertise in oncology drug development, a proven ability to drive cross-functional teams, optimizing team alignment, governance, and overall team health. The PTL will be entrusted with critical oversight of investment recommendations, continuous optimization of asset strategies, ensuring alignment with Janux’s broader portfolio objectives.
ESSENTIAL FUNCTIONS AND RESPONSIBILITIES
- Architect and execute comprehensive lifecycle strategies that maximize the value of the asset for patients, physicians, payors, and Janux as an organization.
- Ensure alignment with corporate objectives and deliver sustained impact across the portfolio.
- Create and communicate a compelling vision for designing, conducting, and executing innovative clinical development plans through registration.
- Develop and contribute to overall strategy for specific diseases/indications, ensuring a franchise-wide portfolio perspective.
- Provide strategic insights and recommendations to optimize clinical development plans.
- Anticipate and proactively address challenges across the development continuum, including risk assessment, mitigation planning, and adaptation to evolving regulatory and competitive landscapes.
- Collaborate closely with Clinical Development, Regulatory Strategy, and Clinical Operations to deliver high-quality drug approval applications, ensuring successful regulatory outcomes and market access.
- Collaborate with cross-functional teams to continuously refine clinical strategies, leveraging translational science, real-world evidence, and stakeholder feedback to optimize program outcomes.
- Lead and develop a cross functional asset team comprised of Clinical Development, Clinical Sciences, Clinical Operations, Clinical Pharmacology, Program Management, Translational Oncology, CMC, Regulatory,and other functions as determined by the organization’s needs.
- Foster an effective, ethical, and inclusive culture that encourages teamwork, peer review, cooperation, and continuous improvement.
- Champion diversity of thought, accountability, integrity, and process excellence.
- Collaborate closely with leaders in Research, Development, Regulatory, and other key functional areas.
- Build and maintain relationships with external leaders, physicians, and patient advocacy groups.
- Be recognized internally and externally as an expert in the field, representing the organization at speaking engagements and industry forums.
- Perform other duties as assigned.
Strategy and Execution
Drug Development Experience
Leadership and Matrix Management
Stakeholder Engagement and Communication
EDUCATION, EXPERIENCE, KNOWLEDGE, SKILLS AND ABILITIES
- PhD, PharmD, or other advanced degree preferred.
- Greater than 10 years of extensive clinical trial, drug development, and regulatory experience, with a strong scientific background.
- Demonstrated ability to lead through influence, managing project teams in a matrix environment rather than direct line management.
- Significant late-stage clinical development experience and exposure to different therapeutic modalities. Oncology and autoimmune experience are highly desirable.
- Domestic and international travel may be required.
Travel Requirements
Job Type: Full-time
Benefits:
· 401K
· Medical insurance
· Dental insurance
· Vision insurance
· Supplemental disability insurance plans
· Flexible schedule
· Life insurance
· Flexible vacation
· Sick time
· Incentive stock option plan
· Relocation assistance
Schedule:
· Monday to Friday
Work authorization:
· United States (Required)
Additional Compensation:
· Annual targeted bonus %
Work Location:
· On site (San Diego, CA)
EQUAL OPPORTUNITY EMPLOYER:
Janux Therapeutics, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from retaliation for protected activity.
Notice to Recruiters and Third-Party Agencies
The Talent Acquisition team manages the recruitment and employment process for Janux. To protect the interests of all parties involved, Janux will only accept resumes from a recruiter once a fully-executed search agreement is in place. Agencies are hereby specifically directed not to contact Janux employees directly in an attempt to present candidates. Janux will consider any candidate for whom an Agency and/or Recruiter has submitted an unsolicited resume to have been referred, free of any charges or fees.