Manager, Project Management Operations

Janux Therapeutics
Janux Therapeutics

Administration, Operations

San Diego, CA, USA

USD 132k-147k / year + Equity

Posted on Aug 14, 2026

Janux Therapeutics is seeking a highly organized and proactive Manager, Project Management Operations, to support our expanding portfolio of oncology and autoimmune programs. This individual will serve as a key operational partner to the Program Management and Clinical Operations organizations by driving project planning, maintaining integrated development timelines, and leading the implementation and optimization of Smartsheet across cross-functional teams.

The ideal candidate combines deep expertise in project management systems, particularly Smartsheet, with hands-on experience supporting oncology and autoimmune drug development programs through critical milestones, including IND submissions and early clinical development. This role offers an opportunity to help establish scalable project management infrastructure while contributing directly to the advancement of innovative therapies for patients.

ESSENTIAL FUNCTIONS AND RESPONSIBILITIES

    Smartsheet Implementation & Administration

    • Serve as the internal Smartsheet subject matter expert and primary administrator.
    • Lead implementation, configuration, and optimization of Smartsheet across Program Management, Clinical Operations, CMC, and other development functions.
    • Design, build, and maintain project plan templates, dashboards, reports, and automated workflows.
    • Drive standardization of project planning processes and reporting methodologies across programs.
    • Design, build, and optimize automated reporting systems for program and clinical study metrics, improving data accuracy, visibility, and operational efficiency
    • Provide training, support, and best practices to end users throughout the organization.

      • Project Planning & Timeline Management

      • Develop, maintain, and continuously improve integrated cross-functional project plans supporting preclinical and clinical-stage oncology programs.
      • Partner with Program Management, Clinical Operations, Regulatory Affairs, CMC, Translational Sciences, and other functional teams to ensure project timelines accurately reflect program strategies, deliverables, dependencies, and milestones.
      • Monitor critical path activities, identify schedule risks, and proactively escalate potential timeline impacts.
      • Support planning and execution activities associated with regulatory submissions, including IND-enabling activities and IND submissions.

        • Program Operations Support

        • Support program teams through meeting coordination, action item tracking, risk management, and milestone monitoring.
        • Contribute to the development and continuous improvement of project management tools, processes, and governance practices.
        • Provide operational support for candidate nomination, IND planning, and early clinical development activities.
        • Support alliance and partnership activities, as applicable.
        • Other duties as deemed necessary.

EDUCATION, EXPERIENCE, KNOWLEDGE, SKILLS, AND ABILITIES

  • Bachelor's degree in a life sciences, scientific, engineering, or related field.
  • 5+ years of project management, program operations, clinical operations, regulatory operations, or related experience within biotechnology or pharmaceutical drug development.
  • Demonstrated experience supporting oncology and/or autoimmune development programs.
  • Hands-on experience supporting IND submissions and early-stage drug development programs.
  • Advanced expertise with Smartsheet, including implementation, customization, workflow automation, dashboard creation, and project plan development.
  • Experience building and maintaining integrated cross-functional development timelines.
  • Strong understanding of drug development processes across Regulatory, Clinical Operations, CMC, and Translational functions.
  • Excellent organization, communication, and stakeholder management skills.
  • Ability to thrive in a fast-paced, evolving biotech environment.
Job Type: Full-time
Benefits:
· Annual bonus program
· Incentive stock option plan
· 401k plan with flat non-elective employer contribution
· Comprehensive medical insurance with 90-100% employer-paid premiums
· Dental and vision insurance
· HSA, FSA, and supplemental insurance plans (life, disability, accident, critical illness, hospital indemnity)
· Unlimited PTO
· Generous holiday schedule; includes summer and winter company shutdown
· Relocation assistance
Schedule:
· Monday to Friday
Work authorization:
· United States (Required)
Additional Compensation:
· Annual targeted bonus %
Work Location:
· On site (San Diego, CA)
EQUAL OPPORTUNITY EMPLOYER:
Janux Therapeutics, Inc. is an equal opportunity employer that is committed to providing a work environment free of harassment and discrimination based upon a protected category, as well as an environment free from retaliation for protected activity.
Notice to Recruiters and Third-Party Agencies
The Talent Acquisition team manages the recruitment and employment process for Janux. To protect the interests of all parties involved, Janux will only accept resumes from a recruiter once a fully-executed search agreement is in place. Agencies are hereby specifically directed not to contact Janux employees directly in an attempt to present candidates. Janux will consider any candidate for whom an Agency and/or Recruiter has submitted an unsolicited resume to have been referred, free of any charges or fees.

132000 - 147000 USD a year

In addition to a competitive base salary ranging from $132,000 to $147,000, we offer stock options, restricted stock units, a stock purchase plan (ESPP) and a target bonus. Janux also provides a comprehensive benefits package for our employees and their families, which includes medical, dental, vision, and supplemental disability insurance. Relocation assistance may also be available.

Please note that the base salary range is a guideline, and individual total compensation will vary based on factors such as qualifications, skill level, competencies, internal equity, and work location.

See more open positions at Janux Therapeutics