The Position

Sequencing is looking for a Chief of Staff to support the CEO and COO as we scale our operations, deepen our partner ecosystem, and build the internal infrastructure to match our ambitions in genomics and precision health. This is a high-visibility, high-impact role designed for a senior operator who thrives at the intersection of strategy and execution.

You will be the connective tissue across the leadership team, driving the operating cadences, cross-functional programs, and vendor processes that allow the company to move with clarity and speed. This is a build role. You will be stepping into a company that has real momentum and needs someone to architect the systems and rhythms that sustain it.

The Impact

• Drive company execution against strategic priorities by partnering with the CEO, COO, and leadership team to translate strategy into clear plans, ensure alignment, and maintain momentum on the highest-impact initiatives
• Act as a force multiplier for the CEO and COO, helping prioritize focus, structure key decisions, and ensure follow-through on critical initiatives and cross-functional workstreams
• Build and run the company’s operating system, including leadership cadences, planning and review cycles, and decision-making frameworks that improve clarity, accountability, and speed across teams
• Own goal-setting and performance management (OKRs), ensuring tight alignment from company priorities to team execution, surfacing risks early, and driving accountability for results
• Drive cross-functional alignment and unblock execution, working across Product, Bioinformatics, Engineering and Marketing teams to resolve conflicts, clarify ownership, and keep initiatives moving
• Build and scale a centralized vendor and procurement function, standardizing vendor selection, contract negotiation, approval workflows, and renewal tracking across external labs, 3PL, SaaS/AI tools, and other partners to reduce risk, improve speed, and optimize spend
• Lead high-priority, ambiguous projects end-to-end, from problem definition through execution, particularly in areas critical to scaling the business
• Support resource planning and scaling efforts, partnering with Finance and leadership on budgeting, headcount planning, and ensuring strategic priorities are properly resourced
  
  

Dominant and Expressed Traits

• 5+ years in consulting, strategy, or business operations with a track record of owning complex, cross-functional initiatives from definition through execution
• Experience operating in a fast-moving startup or similarly dynamic environment, with the ability to adapt quickly while maintaining focus on outcomes
• Exceptional organizational and execution skills, with the ability to manage multiple high-stakes workstreams and consistently drive them to completion
• Proven ability to build and implement operating systems (e.g., planning cadences, OKRs, reporting, decision frameworks) that teams adopt and rely on
• Strong written and verbal communicator, capable of producing clear, executive-ready materials that drive alignment and decision-making
• High judgment and low ego: able to partner closely with senior leaders, push for clarity, and hold teams accountable while maintaining trust
• Systems thinker who uses process, tools, and data to improve speed, transparency, and reliability of execution
• Intellectual curiosity and comfort with technical domains; interest in genomics, health data, or complex data-driven products is strongly preferred