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Research Associate, Purification Process Development

Synthorx

Synthorx

Waltham, MA, USA
Posted on Friday, August 25, 2023

The Genomic Medicine Unit (GMU) Chemistry, Manufacturing and Control (CMC) group at Sanofi is dedicated to the establishment of best-in-class manufacturing platforms to support development of life-changing advanced cell and gene therapy products, including recombinant AAV, non-viral vectors, and cell therapy products.

The GMU purification process development group is responsible for the development of AAV processes and for supporting viral vector purification from next-generation production platforms to enable high-dose gene therapy programs. The Research Associate, Purification Process Development role requires leadership both inside and outside the laboratory and will rely on industry expertise and the exploration of novel technologies to build robust and efficient purification processes consistent with patient safety standards.

We are looking for a motivated candidate with good communication skills and desire to learn advanced purification methods and contribute to organizational goals.

Key Responsibilities:

  • Support the execution and data analysis for viral vector purification process development experiments

  • Work with risk group 2 infectious materials, follow safe lab procedures and maintain good laboratory practices (GLPs)

  • Contribute to technical reports and protocols

  • Support maintenance of facility infrastructure and management of biochemical reagent, buffer components and standard inventories, as well as other support requirements

  • Collaborate with team to identify areas for improved operational excellence

  • Stay updated on new, relevant technologies and published literature to support innovation within the group

  • Support new technology evaluations to increase product purity and improve process understanding

  • Communicate effectively with teams, demonstrate good work ethics and display sound technical judgement

  • Perform weekend and holiday work to support on-going lab activities

Basic Qualifications

  • Bachelor’s degree in biological science or engineering discipline

  • Knowledge and understanding of purification of biologics and/or viral vector systems

  • Familiarity of purification technologies and operations such as filtration, AKTA chromatography systems, TFF, etc.

  • Demonstration of good organization skills, record keeping, and maintenance of a safe work environment

Preferred Qualifications

  • Experience with various purification techniques

  • Motivated and self-directed with commitment to meet aggressive timelines

  • Ability to work on multiple tasks simultaneously

  • Ability to work under moderate supervision and function within a collaborative / team-oriented environment

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.