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Global Research Postdoctoral Fellow - Structural Biology Innovation

Synthorx

Synthorx

Cambridge, MA, USA
Posted on Saturday, September 16, 2023

Our Team:

Our structure biology team embedded within the vibrant scientific environment of Large Molecules Research at Sanofi in Cambridge Crossing has an exciting postdoc opportunity for a structure biologist to accelerate biologics discovery. The postdoc will work as a valued team member to apply the latest advances in structural biology and biophysics within our research portfolio while playing a role in Sanofi’s ongoing efforts to reinvent drug discovery. Click the link below for more information about Sanofi's Postdoctoral careers. Sanofi's Postdoctoral Program | Careers at Sanofi

Main Responsibilities:

The successful candidate is a team player with excellent communication skills, has expertise in all aspects of cryoEM from sample preparation, data collection, data processing through 3D reconstruction, and will establish a molecular cryo ET and AI/ML enhanced hybrid microscopy workflow to visualize large conformational dynamics in therapeutically relevant protein complexes.

About You

Experience:

  • Structure biology and/or Cryo-EM research contributions demonstrated through authorship in peer-reviewed publication(s)

Soft skills:

  • Self-motivated, innovative, and able to handle multiple challenging projects in parallel

  • Excellent presentation skills to communicate structural biology findings, and enhance team-based progress

  • Ability to work independently, and effectively within timelines and collaborate in a highly multidisciplinary environment

Technical skills:

  • Expertise in cryo-EM grid preparation, screening, and data collection

  • Ability to Single particle EM data processing, three-dimensional structure determination, and model building

  • Basic understanding of Linux terminal usage/shell-scripting is required. Experience in cloud computing, Python scripting and understanding of AI/ML applications in structural biology is a plus.

Education:

  • PhD in protein biochemistry, biophysics, structural biology, or related discipline.

Languages: English

Preferred qualifications:

  • Protein purification, analytical and biophysical characterization

  • CryoET sample preparation, data collection and processing

  • Protein engineering and in silico protein design

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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