Senior Scientist, Neurodegenerative Diseases
We are looking for a highly qualified and motivated Scientist to join the Neurodegenerative Diseases Cluster located in Cambridge, MA. The ideal candidate will have a Ph.D. and postdoctoral training in neurodegeneration or a related field, with a passion for drug discovery. This laboratory-based position will focus on discovering, validating, and developing therapies for neurodegenerative diseases, including Alzheimer’s, Parkinson’s, and ALS.
The successful candidate will be responsible for designing and executing experiments to identify and confirm new therapeutic targets. This hands-on role will involve integrating cutting-edge bulk and single-cell RNA sequencing data using benchwork and bioinformatics tools for target credentialing in diseases like Alzheimer’s and Parkinson’s. In addition to analyzing, recording, and reporting data, the candidate will be expected to develop and learn new techniques and execute multiple projects simultaneously with appropriate supervision.
Key responsibilities also include leading project teams, collaborating effectively with internal and external partners to advance ongoing exploratory and portfolio projects, and participating in new target identification and validation to support current and future drug discovery programs. The candidate should have expertise in CNS disease biology, in vivo pharmacology, cellular and molecular biology, protein biochemistry, proteomics, transcriptomics, CRISPR, and other approaches to identify and validate targets and pathways.
This exciting role offers scientists the opportunity to be intimately involved in early discovery research and pre-clinical development. The candidate should possess broad knowledge of neurobiology and the demonstrated ability to contribute technical skills and functional knowledge as part of a dynamic team. If you are a motivated scientist with a strong background in neurodegenerative diseases and a keen interest in advancing therapeutic solutions, we encourage you to apply and join our team.
Generate transcriptomic, proteomic, and lipidomic datasets to credential pathway targets and generate new leads
Develop tools to model neurodegenerative disease in vitro using primary rodent and human cell cultures and human iPSC cells to evaluate the biological functions of target molecules.
Validate in vivo mouse and rat models of neurodegeneration to measure target engagement and tease apart disease mechanisms.
Design and execute experiments, analyze data and clearly communicate results at internal and external meetings and conferences.
Interact in a matrixed, dynamic and cross-functional manner across the Rare and Neuroscience Therapeutic Area, Research Platforms, and external collaborators.
Establish and maintain a scientific network external to the company to advance portfolio projects through collaborations, licensing opportunities and business development.
Help guide new drug candidates from the early exploratory discovery stage to the clinic.
Qualifications, Competencies and Characteristics:
Ph.D. in neuroscience, neurodegeneration, neuroimmunology, or related field with >3 years of postdoctoral training or M.S. with 7 years of industry experience.
Expertise in neurodegenerative disease and experience with cell- and animal-based disease models.
Understanding of target identification of complex CNS disorders and in vivo pharmacology and/or molecule biodistribution in rodents or NHPs.
Expertise in bulk and single-nucleus transcriptomics, interpretation of multi-omics data using platforms such as Bioturing, Qiagen.
Experience in microscopy-based imaging assays of synaptic function.
Outstanding track record of publications in neurodegenerative disease, and/or related areas.
Familiarity with bioinformatics databases and tools such as R, Python or GitHub preferred
Extensive experience with both in vivo and in vitro models and tools preferred.
Ability to work collaboratively to identify and execute key steps necessary to advance projects in a time- and resource-sparing fashion.
Ability to effectively develop and discuss experimental goals and research progress with scientists and stakeholders of varied backgrounds.
Excellent analytical, presentation and writing skills.
Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.
At Sanofi diversity and inclusion is foundational to how we operate and embedded in our Core Values. We recognize to truly tap into the richness diversity brings we must lead with inclusion and have a workplace where those differences can thrive and be leveraged to empower the lives of our colleagues, patients and customers. We respect and celebrate the diversity of our people, their backgrounds and experiences and provide equal opportunity for all.