Tolebrutinib, one of Sanofi’s priority assets and a key pillar of the Neurology Franchise, is the first brain-penetrant, bio-active Bruton’s tyrosine kinase inhibitor in multiple sclerosis (MS), with the broadest pivotal program ever, spanning the entire spectrum of MS. Supported by phase 3 results, tolebrutinib may change the practice of medicine in MS by offering a unique approach to controlling disability accumulation.

The FDA has granted Breakthrough Therapy designation for tolebrutinib in nrSPMS. Regulatory filing is underway, with submission to the FDA and EMA completed earlier this year, and more to come over the next months.

The PERSEUS phase 3 study in primary progressive MS (PPMS) patients is ongoing, with data expected in H2 2025.

The Global Market Access & Pricing Director for tolebrutinib will be part of the Global Market Access and Pricing Neurology Team and contribute to the global pricing and access strategy of tolebrutinib across its MS indications, with focus on indication expansion to PPMS, as well as support the end-to-end execution of the strategy.

This includes:

• Contributing to the development of the payer value & pricing positioning for tolebrutinib, assessing the impact of the ph3 clinical trial outcomes in PPMS on launch prices & access

• Driving the development of a compelling value story & messaging, integrating the PPMS trial results into tolebrutinib overall payer value story

• Contributing to the preparation of the PPMS Go-to-file internal governance and scenario planning in partnership with the GPT and wave 1&2 countries

• Providing end-to-end market access support to countries to drive excellence in pricing & access strategy execution

Given the highly competitive MS market, as well as our ambition to change the treatment paradigm in MS with tolebrutinib, novel approaches and best in class methodologies will need to be fully leveraged to shape an optimal strategy in PPMS and realize tolebrutinib’s full pricing and access potential across its target indications.

This is a highly collaborative role requiring a strong cross-functional approach with all key business partners (Commercial, Medical, Clinical, Biostats, Regulatory Affairs, Public Affairs...), Market Access (HEVA, CoE) and countries.

We are an innovative global healthcare company, committed to transforming the lives of people with immune challenges, rare diseases and blood disorders, cancers, and neurological disorders. From R&D to sales, our talented teams work together, revolutionizing treatment, continually improving products, understanding unmet needs, and connecting communities. We chase the miracles of science every single day, pursuing progress to make a real impact on millions of patients around the world.

Main Responsibilities:

• Maintain a high level of knowledge with regards to the scientific, clinical and commercial developments of the multiple sclerosis market, and monitor the environment for market access drivers and threats & opportunities, to make informed decisions about payer strategy, plans and tactics

• Contribute to the development of tolebrutinib’s access and pricing strategy in partnership with the Global Brand / Global Project Teams and key countries, taking a holistic approach to optimize brand value across the planned indications

• Drive development of key pricing & market access deliverables (market access blueprint, value story, global pricing policy informed by pricing research, contracting strategy including value-based / outcomes-based frameworks, country launch sequencing, negotiation guide and objection handler)

• Identify evidence gaps needed to secure tolebrutinib access across key markets (epidemiology, patient outcomes / RWE, cost-effectiveness, budget impact, …) and work cross-functionally to provide solutions to address gaps

• Provide market access and pricing input into tolebrutinib forecasting / launch scenarios

• Build materials and provide support for internal governance reviews related to tolebrutinib’s market access strategy (TARC, DWG, IDCC, GMAx Committee)

• Contribute to the preparation of the MS GMAx Sub-Team ensuring relevant input and engagement from priority markets and relevant functions

• Fully embrace Sanofi’s Glocal model by partnering with country MAx leads to ensure global market access deliverables are developed optimally and on time to support payer negotiations

• Contribute to payer mock negotiation workshops and build resulting negotiation guide and objection handler to support country payer interactions

• In conjunction with Commercial and the Global Market Access and Corporate Affairs Excellence team, conduct reviews of country business cases of major markets for approval of payer submission and launch; identify opportunities for improvement and work with markets to strengthen country submissions and their local engagement plans

CORE BEHAVIORAL COMPETENCIES

• Push to go beyond the level we have operated until now: constantly challenge the status quo focusing on the priorities that will deliver the best outcomes and letting go what won’t: be intolerant to mediocracy, believe we can and must do better and aim at higher but never at the expenses of our values and judgment

• Put the interest of the organization ahead of your own or those of your team: consider both short- and long-term impact of decisions; put collective and global goals above individual or local goals; share resources and capabilities with those with the greatest need and impact; enable decision making at appropriate level

• Act in the interest of our patients and customers: actively engage with customers to know their current and future needs; bring an external perspective into decisions

• Take action and don’t wait to be told what to do: take smart and informed best bets with the information at hand and anticipate the consequences of your actions; use personal judgement and others’ advice to make bold and impactful decisions which move us forward

About You

SKILLS, EXPERIENCE & KNOWLEDGE REQUIREMENTS

• Master’s degree in science, business, or related discipline

• At least 10 years of experience in reimbursement/pricing/market access with an accomplished track record of developing and/or executing successful global strategies across the product lifecycle

• Additional experience at local / regional level with in-depth knowledge of at least one major market, preferably the US strongly desired

• Strong strategic and leadership skills as well as analytical skills to translate clinical information and messages into clear payer access strategies / recommendations

• Flexibility and demonstrated ability to work across multiple projects and priorities as well as across diverse and complex payer archetypes in the US and ex-US geographies

• Outstanding written and oral communication skills, including the ability to effectively write and deliver presentations to professionals at all levels in a straightforward way

• Strong business acumen, analytical and financial skills to evaluate investment strategies; comfortable with product forecast and P&L

• Demonstrated relationship building at all levels of the organization and across geographies; experience of working collaboratively and cross-functionally

• Knowledge of multiple sclerosis market / Neurology preferred as well as HEOR working experience and exposure to clinical development

• Language: fluent English required

Why Choose Us?

• Bring the miracles of science to life alongside a supportive, future-focused team.

• Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally.

• Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact.

• Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave.

Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law.

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