Post-Doc Position in Sanofi / WIDGET consortium

Expert in Biology, Molecular Biology, NGS & Single Cells

Abstract:

As part of the WIDGeT consortium1 (23M€, 5 years), we are currently researching a Postdoctoral candidate with a strong background in molecular biology and NGS for single cell application.

Overview of the research project:

The WIDGeT consortium (Viral Vector Intelligent Design for Gene Therapy) aims to accelerate the development of gene therapies using viral vectors derived from adeno-associated viruses (AAV) for the treatment of age-related macular degeneration and hereditary podocytopathies (kidney diseases), leveraging the potential of artificial intelligence (AI). As part of this challenging consortium, our team proposed to develop a new technology to provide very sensitive information of AAV’s transgene expression at the single cell level. This technology is based on droplet microfluidic, DNA barcoded, scRT-PCR and NGS.

Responsibilities:

· Develop, design, and execute complex experiments and analyze data.

· Write (Lab Book) and Present (PowerPoint) research findings.

· Mentor and co-supervise engineer, technician and undergraduate students involved in the research project.

· Report and collaborate with other members of the consortium.

Qualifications :

· Ph.D. in biology or molecular biology

· Strong Experience in Single-cell RNA sequencing

· Strong background in molecular biology, NGS experiments and analysis.

· Background in single cells experiment (10x, flow cytometer...)

· Appetite for bench work & wet lab

· Appetite for challenging project

· Background in Bioinformatic

· Familiarity with statistical software (Prism, Spotfire, other…)

· Fluent in English

· Excellent written and verbal communication skills.

· Experience with Recombinant AAV is a plus.

· Knowledge in organoids/tissues preparation is a plus.

· Experience in screening is a plus.

· Background in Droplet microfluidic is optional.

The Project Team:

A dedicated team was created in 2024 to tackle this challenging project. The team is composed of one researcher, one engineer and one technician.

The Lab:

Our innovative Team (~8 people) is based in Vitry-Sur-Seine (Suburbs of Paris) at Sanofi R&D site. We have two laboratories (L1 & L2) dedicated to droplet microfluidic technology, with access to diverse technologies (ARIA Fusion (FACS), PCR, qPCR and NextSeq Illumina).

Duration & Salary:

18 months to 4 years

Language:

English / French (optional)

References:

1Sanofi, WhiteLab Genomics, the TaRGeT Laboratory at Nantes University, and Institut Imagine launch WIDGeT to make France a global leader in gene therapy. | Institut Imagine

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