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Head of Site OPEX and Smart Factory

Synthorx

Synthorx

Singapore
Posted on Jan 19, 2026
Key Accountabilities

Developing, owning, and maintaining the Site Performance Roadmap by:

  • Leading the Strategy Cascading process by working closely with internal (i.e., SLT) and external (i.e., Global Functions) stakeholders, defining site CBN’s

  • Drive internal/external benchmarking & analyses to identify performance

gaps/opportunities vs. best in class, socializing it internally and externally with key

stakeholders

  • Leading the performance & digital piece during Strat Plan and Budget, defining

performance ambition (aligned with CBN’s and GBU objectives), cascaded into

financial/operational targets across all performance dimension (e.g., +QDCI,

scorecard)

  • Developing a prioritized portfolio of initiatives (i.e., performance + modernization)

to deliver site ambition, and related: impact, resourcing, and timelines

Delivering performance ambition by leading the execution of the Site Performance

Roadmap through:

  • Focused transformation initiatives (e.g., performance boosters), when fast-paced performance breakthroughs are required

  • Standardization through SMS 2.0 ecosystem deployments enabling continuous

improvement (incl. execution support, CI standard deployment, problem solving,

OpEx method, etc.)

  • Deployment of Smart Factory solutions (incl. AI) and associated change

management to ensure value realization and expected transformation (e.g.,

Modernization Index)

  • Supplier Excellence: Own the Material & Supplier improvement initiatives (i.e.,

Supplier Excellence) & business interface of the procurement on site

Leading site performance governance by:

• Manage operational KPI management (i.e., +QDCI) including cascaded reviews

from shopfloor to SLT to track performance evolution vs. ambition

• Drive financial impact of performance actions (e.g., 3P, Sievo) ensuring value is

maximized and captured in alignment with Finance, Procurement, Operations

• Monitor overall performance trajectory vs. ambition, spot early on (risk of)

deviations and decide appropriate corrective actions

• Represent the site in above site performance reviews and forums (e.g., L4-L5)

Leading Site SMS team and developing OpEx & Digital capabilities & performance culture

• Implement Site OpEx & Smart Factory team in alignment with standard

organization

• Modernize OpEx capabilities by developing strong digital (e.g., Data Analytics, AI,

Connectivity) profiles

• Drive OpEx and Digital training in alignment with the learning administrator

• Develop strong relationships with the global OpEx community and the Global

Qualification and experience

Expected Experience:

Knowledge of main Operational Excellence techniques (e.g., Lean, Six Sigma, Agile, CI, etc.)

• Experience in transformation and change management

• Understanding of data analytics / visualization

Expected Technical skills

• Project Management

• Basics of finance and strategy

• Knowledge of main IT/Digital solutions (e.g., ERP)

• Knowledge of Manufacturing 4.0 (Paperless manufacturing operation with integrated information flow across different platform across SAP, MES, Delta V, Historian, LIMS etc)

• Knowledge and proven application of AI/Gen AI tools

Knowledge of key business & pharma processes

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